Molecular diversity – the toolbox for synthetic gene switches and networks

04.04.2011

Weber W, Fussenegger M.

Curr Opin Chem Biol. 2011;15(3):414-20.

Curr Opin Chem Biol      online article

The rapid development of synthetic biology is a paradigm of how the molecular diversity of naturally occurring gene control components can be used to design synthetic control devices. Here we offer an overview on recent advances in the modular design of trigger-inducible mammalian expression devices that are either responsive by exogenous stimuli such as chemicals and physical cues or controlled by endogenous metabolites driving prosthetic circuits to treat metabolic disorders in a self-sufficient manner.