X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution

03.10.2011

Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C.

Biochim Biophys Acta. 2011; 1807(12):1606-15

The respiratory cytochrome bc1 complex is a fundamental enzyme in biological energy conversion. It couples the electron transfer from ubiquinol to cytochrome c with the generation of proton motive force which fuels ATP synthesis. The X-ray structure of the fully functional complex from the soil bacterium Paracoccus denitrificans was determined at 2.7-Å resolution. This model for the medically relevant mitochondrial complexes can now be used to analyze structure/function relationships and drug binding.

X-ray structure of the dimeric P. denitrificans cyt bc₁^?ac complex with one monomer in transparent surface representation and the other one in ribbon presentation

BIOSS

X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution