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Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Events

BIOSS

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/b-catenin target gene expression

02.08.2012

Wallmen B, Schrempp M, Hecht A

Nucleic Acids Res. 2012; 40(19):9455-69

Nucleic Acids Research online article

In this study we demonstrate that acute transcriptional activation of cell-type-specific Wnt/?-catenin targets requires certain Tcf/Lef DNA binding proteins. However, Tcf/Lef proteins can neither generate the transcriptionally poised chromatin state of their targets nor are they needed for its maintenance. The inability to cope with chromatin uncovers a property of Tcf/Lef proteins that prevents false ectopic induction and ensures spatio-temporal stability of Wnt/?-catenin target gene expression.