News

Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Events

BIOSS

mHERC6 is the essential ISG15 E3 ligase in the murine system

23.11.2012

Ketscher L, Basters A, Prinz M, Knobeloch KP

Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40

Biochem Biophys Res Commun online article

Within this study it is shown that the murine HECT ligase mHERC6 is strongly induced by different pathogen-associated molecular patterns in a type I Interferon dependent manner. Together with the relatively low inducibility of mHERC6 by IFN-? our observations suggest that mHERC6 and ISGylation are basically induced by IFN-?.