Mussel-mimetic tissue adhesive for fetal membrane repair: An ex vivo evaluation
08.08.2012
Haller CM, Buerzle W, Kivelio A, Perrini M, Brubaker CE, Gubeli RJ, Mallik AS, Weber W, Messersmith PB, Mazza E, Ochsenbein-Koelble N, Zimmermann R, Ehrbar M.
Acta Biomater. 2012; 8(12):4365-70
Iatrogenic preterm prelabor rupture of membranes (iPPROM) remains the main complication after invasive interventions into the intrauterine cavity. Here, the proteolytic stability of mussel-mimetic tissue adhesive (mussel glue) and its sealing behavior on punctured fetal membranes are evaluated. The proteolytic degradation of mussel glue and fibrin glue were compared in vitro. Together with good stability in proteolytic environments, this makes mussel glue a promising sealing material for future applications.
