A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation
06.03.2013
Mischnik M, Boyanova D, Hubertus K, Geiger J, Philippi N, Dittrich M, Wangorsch G, Timmer J, Dandekar T.
Mol Biosyst. 2013;9(6):1326-39
Platelets are critical for haemostasis and blood clotting. Since under normal circumstances blood should flow without clotting, its function is regulated via a complex interplay of signal transduction pathways. Understanding this network is crucial for treatment of cardiovascular and bleeding diseases. Detailed protein interaction and phosphorylation data are used to establish a Boolean model of the central platelet cascades. We show how different signalling events coalesce into a fully activated system state.
