Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
09.12.2013
Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Münz C.
J Cell Biol. 2013;203(5):757-66
Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in macrophages and dendritic cells, a subset of phagosomes gets coated with LC3, a component of the molecular machinery of autophagy, and maintains phagocytosed antigens for prolonged presentation on MHC class II molecules. These LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their generation.
