Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons
01.05.2013
Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik A, Vida I.
J Neurosci. 2013;33(18):7961-7974
Functional GABABRs and their popstsynaptic effector, Kir3 channels, are expressed in hippocampal PV+ cells. Light and electron microscopic analysis revealed that receptor and channel subunits are present in PV+ cells and preferentially
localize to extrasynaptic membrane of dendrites and, to a lesser degree, axon terminals. Whole-cell recordings provided evidence that GABA synaptically released by various interneuron types elicits slow IPSCs in perisomatic-targeting
(PT), but not dendrite-targeting (DT), PV+ cells. In contrast, the synaptic output of both PT and DT cells is modulated by GABABRs, albeit more strongly so in the latter. Computational analysis suggested that GABABRs in PT cells can modulate their discharge dynamically and may contribute to the generation of complex network patterns.
