Global remodelling of cellular microenvironment due to loss of collagen VII
16.04.2013
Küttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J.
Mol Syst Biol. 2013;9:657.
The cellular microenvironment is shaped by soluble factors and structural components, the ECM. A quantitative mass spectrometry strategy was developed to assess proteome differences in the microenvironment of human fibroblasts. The influence of collagen VII (C7), a structural component, which is lost in genetic skin fragility, was used as model. Loss of C7 had a global impact on the microenvironment and was associated with proteome alterations highly relevant for disease pathogenesis.
