Integrating anatomy and function for zebrafish circuit analysis

23.04.2013

Arrenberg AB, Driever W

Front Neural Circuits. 2013;7:74

Front Neural Circuits.        online article

Due to its transparency, virtually every brain structure of the larval zebrafish is accessible to light-based interrogation of circuit function. Advanced stimulation techniques allow the activation of light-gated ion channels and pumps, and genetically encoded calcium indicators report the activity of neurons. To comprehensively understand circuit function, functional maps need to be placed in the context of morphological features, projection patterns, neurotransmitters, and anatomical landmarks. We discuss the prospect of merging functional and anatomical data in an integrated atlas from the perspective of our work on long-range dopaminergic neuromodulation.