Pou5f1-dependent EGF expression controls e-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements
11.03.2013
Song S, Eckerle S, Onichtchouk D, Marrs JA, Nitschke R, Driever W.
Dev Cell. 2013;24(5):486-501
Control of E-cadherin adhesion is essential for gastrulation. Song et al. show that Pou5f1/Oct4 mutant zebrafish embryos accumulate E-cad at the plasma membrane. Mutants lack EGF expression, which in turn controls proper E-cad endocytic trafficking. The dynamics of E-cad trafficking and adhesion is essential for effective cell migration during gastrulation.
