Profile Likelihood in Systems Biology
12.04.2013
Kreutz C, Raue A, Kaschek D, Timmer J.
FEBS J. 2013;280(11):2564-71
Inferring knowledge about biological processes by a mathematical description is a major characteristic of Systems Biology. To understand and predict system’s behavior the available experimental information is translated into a mathematical model. Likelihood profiles have been recently suggested and applied in the Systems Biology for assessing parameter and prediction uncertainty. In this article, the profile likelihood concept is reviewed and the potential of the approach is demonstrated for a model of the erythropoietin (EPO) receptor.
