Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism.
01.01.2013
Schweitzer J, Löhr H, Bonkowsky JL, Hübscher K, Driever W.
Development. 2013 Jan 1;140(1):93-106
How transcription factors genetically specify axonal pathfinding mechanisms in the CNS has remained a challenging open topic in neurobiology. This study provides first insights into the mechanisms that accomplish long distance migration of growth cones navigating along the longitudinal axis through territories of varying concentrations of guidance cues. Sim1a and Arnt2 regulate receptor expression during hypothalamo-spinal longitudinal growth navigation to ensure proper lateral positioning.
