A mutation in cnot8, component of the Ccr4-Not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons
05.12.2014
Koch P, Löhr HB, Driever W.
PLoS One. 2014 Dec 5;9(12):e113829
While regulation of the activity of developmental control genes at the transcriptional level as well as by specific miRNA-based degradation are intensively studied, little is known whether general cellular mechanisms controlling mRNA decay may contribute to differential stability of mRNAs. We investigate effects of the cnot8m1061 mutation in the deadenylation dependent mRNA decay pathway on developmental mechanisms, using dopaminergic differentiation in the zebrafish brain as model system. Our data indicate that attenuation of Cnot8 activity differentially affects mRNA levels of developmental control genes.
