Activation of the TCR complex by peptide-MHC and superantigens
2014
Louis-Dit-Sully C, Blumenthal B, Duchniewicz M, Beck-Garcia K, Fiala GJ, Beck-García E, Mukenhirn M, Minguet S, Schamel WW.
EXS. 2014;104:9-23.
In this BIOSS review, we summarize the current knowledge on the activation of the T-cell antigen receptor (TCR) by the natural antigens: foreign peptides presented by major histocompatibility complex molecules (MHCp) and bacterial superantigens. MHCp that binds with sufficient affinity to TCR?? thereby elicits phosphorylation of the cytoplasmic tails of the TCR?? -associated CD3 subunits. This is the initial step in T cell activation.
