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Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

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BIOSS

Epigenetics in cardiac development, function, and disease

13.05.2014

Nührenberg T, Gilsbach R, Preissl S, Schnick T, Hein L.

Cell Tissue Res. 2014;356(3):585-600.

Cell Tissue Res. online article

Substantial new knowledge has accrued, over the past few years, concerning the epigenetic regulation of heart development and disease. Epigenetic mechanisms comprise DNA methylation, ATP-dependent chromatin remodeling, histone modifications, and non-coding RNAs. Cardiac development and disease are linked through the reactivation of fetal genes upon cardiac hypertrophy and failure. In cardiac disease, changes in gene expression are accompanied by distinct changes in histone modifications.