Progressive replacement of embryo-derived cardiac macrophages with age
22.09.2014
Molawi K, Wolf Y, Kandalla PK, Favret J, Hagemeyer N, Frenzel K, Pinto AR, Klapproth K, Henri S, Malissen B, Rodewald HR, Rosenthal NA, Bajenoff M, Prinz M, Jung S, Sieweke MH.
J Exp Med. 2014 Oct 20;211(11):2151-8
Cardiac macrophages (cM?) are critical for early postnatal heart regeneration and fibrotic repair in the adult heart, but their origins and cellular dynamics during postnatal development have not been well characterized. Tissue macrophages can be derived from embryonic progenitors or from monocytes during inflammation. We report that within the first weeks after birth, the embryo-derived population of resident CX3CR1(+) cM? diversifies into MHCII(+) and MHCII(-) cells. Genetic fate mapping demonstrated that cM? derived from CX3CR1(+) embryonic progenitors persisted into adulthood but the initially high contribution to resident cM? declined after birth.
