An Env-derived multi-epitope HIV chimeric protein produced in the moss Physcomitrella patens is immunogenic in mice
05.12.2014
Orellana-Escobedo L, Rosales-Mendoza S, Romero-Maldonado A, Parsons J, Decker EL, Monreal-Escalante E, Moreno-Fierros L, Reski R.
Plant Cell Rep. 2015;34(3):425-33
This is the first report on the recombinant production of a candidate vaccine in the moss system. A multi-epitope protein from the Human Immunodeficiency Virus based on epitopes from gp120 and gp41, named poly-HIV, was designed and produced in moss. Immunization with plant extracts expressing the poly-HIV protein elicited specific antibodies in mice, reflecting the immunogenic potential of this moss-derived HIV antigen.
