Do not judge a cell by its cover-diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation

07.08.2015

Brendecke SM, Prinz M.

Semin Immunopathol. 2015;37(6):591-605.

Semin Immunopathol.            online article

Specialized populations of tissue-resident myeloid cells inhabit every organ of the body. While many of these populations appear similar morphologically and phenotypically, they exhibit great functional diversity. The central nervous system (CNS), as an immune privileged organ, possesses a unique tissueresident macrophage population, the microglia, as well as numerous myeloid cell subsets at its boarders and barriers in CNS-adjoining tissues, namely the meninges, the perivascular space, and the choroid plexus. Recent research has added much to our knowledge about microglia, whereas the populations of CNS-surrounding phagocytes are just starting to be appreciated.