Optogenetic control of signaling in mammalian cells
12.09.2014
Beyer HM, Naumann S, Weber W, Radziwill G.
Biotechnol J. 2015;10(2):273-83
Optogenetic tools allow the targeting of specific signaling nodes for a precise spatiotemporal control of downstream effects. In this review, we summarize the photoreceptors and the light-based mechanisms utilized for the modulation of signaling. We discuss in detail optogenetic tools and approaches applied to control signaling events in mammalian cells. Applying the latest generation of optogenetic tools allows to control cell fate decisions such as proliferation and differentiation or to deliver therapeutic substances in a spatiotemporally-controlled manner.
