News

Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Events

BIOSS

Structural insights into Ca(2+)-calmodulin regulation of plectin 1a-integrin ?4 interaction in hemidesmosomes

19.02.2015

Song JG, Kostan J, Drepper F, Knapp B, de Almeida Ribeiro E Jr, Konarev PV, Grishkovskaya I, Wiche G, Gregor M, Svergun DI, Warscheid B, Djinovi?-Carugo K.

Structure. 2015;23(3):558-70.

Structure online article

Hemidesmosomes attach the top level of skin to plasma membrane via the assembly between integrin alpha-6/beta-4, plectin, and intermediate filaments. Hemidesmosome disassembly and remodeling are regulated by phosphorylation and Ca 2+. We provide a structural mechanism of how Ca 2+/CaM shunts integrin alpha-6/beta-4 and F-actin from the assembly with plectin.