BIOSS
Centre for Biological Signalling Studies

The great migration of Bax and Bak.

23.01.2015

Edlich F

Mol Cell Oncology 2015;2:3,e995029

Mol Cell Oncology.            online article

The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported thatBak is also present in the cytosol of healthy cells and that Bax and Bak are regulated by the same retrotranslocation process.