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Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Events

BIOSS

ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response

10.09.2015

Roodbarkelari F, Du F, Truernit E, Laux T.

BMC Biol. 2015 Sep 10;13:74.

BMC Biol. online article

We addressed whether stem cell maintenance by ZWILLE (ZLL) involves regulation of auxin. In zll-1 mutants, expression of the auxin response reporter DR5:GFP is elevated, and transcription of the AUXIN RESPONSE FACTOR 2 (ARF2) gene is upregulated. Downregulation of ARF2 significantly restores stem cells in zll-1 mutants, whereas increased expression of ARF2 enhances differentiation. Upregulation of the ZLL effector gene REVOLUTA restores ARF2 expression and stem cell maintenance in zll-1 embryos.