DNA methylation signatures follow preformed chromatin compartments in cardiac myocyte
Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R.
Nat Commun. 2017;8(1):1667.
The mutual dependencies between chromatin organization and patterns of epigenetic marks, including DNA methylation, remain poorly understood. Here, we demonstrate that establishment of A/B-compartments precedes and defines DNA methylation signatures during differentiation and maturation of cardiac myocytes. Thus, DNA methylation appears to be established in preformed chromatin compartments and may be dispensable for the formation of higher order chromatin organization.
