Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions
Hessenberger M, Zerbes RM, Rampelt H, Kunz S, Xavier AH, Purfürst B, Lilie H, Pfanner N, van der Laan M, Daumke O.
Nat Commun. 2017;8:15258
We show that Mic60, a central component of the mitochondrial contact site and cristae organizing system, plays a dual role. Mic60 not only forms contact sites with the mitochondrial outer membrane but also displays membrane-shaping activity for the inner membrane of mitochondria.
