Biofunctionalized materials featuring feedforward and feedback circuits exemplified by the detection of Botulinum Toxin A

Adv Sci.                online article

Feedforward and feedback loops are key regulatory elements in cellular signaling and information processing. Here, we incorporate feedforward and positive feedback circuits into biohybrid polymer materials in order to develop signal-sensing and signal-processing materials systems. This concept is exemplified by the synthesis of a materials system able to sensitively detect the botulinum neurotoxin A. The flexible design could be easily adapted to detect other toxins or molecules of interest.