Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development

Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR.

Nat Commun.                   online article

Popovitchenko and colleagues report on the post-transcriptional regulation of the RNA-binding protein Elavl4 via it’s 5’UTR during cortical brain development in radial glia and early neurons. This regulation impacts on glutamatergic neuron development.