What determines the sorting of closely related membrane proteins to either the ER or mitochondria?

Prof. Sabine Rospert (Institut of Biochemistry and Molecular Biology , ZBMZ)

The biogenesis of membrane proteins is essential for signaling processes. One central question is how very similar transmembrane domains of ER- and mitochondrial proteins ensure targeting to the correct compartment. We aim to understand how the interplay between nascent membrane proteins, the ribosome, and ribosome-bound protein biogenesis factors impact on the fidelity of protein sorting.