Funded projects 2012-2015

Funded projects within Area A

• Nano-scale analysis of the X chromosome using super-resolution microscopy (Dr. Asifa Akhtar)
• Role of TPC1 channels and associated proteins in NAADP-mediated Ca2+ release and vesicle exocytosis (Molecular physiology of renal TPC1 channels) (Dr. Uwe Schulte, Prof. Gerd Walz)
• Dynamics and Regulation of Respiratory Chain Biogenesis in Mitochondria (Prof. Bettina Warscheid, PD Dr. Martin van der Laan)
• Characterizing a multi-protein sensor of mitochondrial damage regulating membrane dynamics, mitochondrial integrity and auto/mitophagy (Prof. Ralf Baumeister)
• Regulatory role of signal sequence modification in mitochondrial biogenesis and protein quality control (Dr. Thomas Becker, Prof. Chris Meisinger)
• Significance of the protein constituents of native AMPA receptors for operation and dynamics of excitatory synaptic transmission in the mammalian brain (Functional proteomics of AMPA receptors) (Prof. Bernd Fakler, Dr. Jochen Schwenk)
• Structure and mechanism of membrane signaling complexes (Prof. Carola Hunte)
• Quantitative analysis of axonal Ca2+ channels in cortical GABAergic neurons (PD Dr. Akos Kulik)
• Epigenetics of zebrafish Midblastula Transition: connection with Pou5f1 and SoxB1 transcriptional regulators (Dr. Daria Onichtchouk)
• Link between mitochondrial biogenesis, cellular metabolism and cell cycle regulation (PD Dr. Nils Wiedemann, Prof. Klaus Pfanner)
• What determines the sorting of closely related membrane proteins to either the ER or mitochondria? (Prof. Sabine Rospert)

Funded projects within BIOSS B:

• Signals and Control Mechanisms regulating Axial Stem Cells required for Posterior Body Axis Elongation during Mouse Embryogenesis (Prof. Sebstian Arnold)
• Microenvironment remodeling by the degradome of breast cancer stem cells (Prof. Dr. Thomas Reinheckel, Prof. Christoph Peters, PD Dr. Oliver Schilling)
• Controlling cell polarization, directional migration and wound healing by highprecision pH manipulation (Prof. Matias Simons)
• Regeneration of vertebrate kidneys (Prof. Gerd Walz)
• Impact of the active Nlrp3 inflammasome on signalling in regulatory T cells shaping the tumour microenvironment (PD Dr. Robert Zeiser)
• Interaction partners of the oncogenic transcriptional repressor ZEB1 as targets to interfere with its oncogenic functions (Prof. Thomas Brabletz)
• Implementation of the BIOSS Cancer Monitor (Dr. Tilman Brummer, Dr. Roland Nitschke, Prof. Christoph Peters, Prof. Wilfried Weber)
• Identification of kinases driving the metastatic behaviour of breast cancer (Dr. Tilman Brummer, Prof. Dr. Thomas Reinheckel, Prof. Christoph Peters)
• Stable synthetic optical switches for optogenetics and optophysiology in zebrafish (Prof. Wolfgang Driever, Prof. Wilfried Weber, Jun. Prof. Dr. Olaf Ronneberger, Dr. Roland Nitschke)
• Mouse models for inducible expression of oncogenic, ITAM-containing viral proteins (Prof. Hassan Jumaa)
• Mathematical modeling of the self organizing Arabidopsis shoot meristem (Prof. Thomas Laux)
• The role of GSK-3 mediated phosphorylation of the acetyltransferase Tip60 for apoptosis and the DNA damage response (Dr. Ulrich Maurer, Dr. Tilman Brummer)
• Dynamics of morphogen gradient formation (Dr. Giorgos Pyrowolakis)

Funded projects within BIOSS C

• An Ethics Framework for Synthetic Biology (Dr. Jochim Boldt)
• Signalling pathway sensors and analysers in living cells (Prof. Gerald Radziwill, Prof. Wilfried Weber)
• Glyco-Design at Golgi membranes (Prof. Ralf Reski)
• Broadband dynamics and cell mechanics within cancer cell spheroids (Prof. Alexander Rohrbach)
• Imaging cell spheroids with light-sheet microscopy using scanned beams with holographic feedback (Prof. Alexander Rohrbach)
• Rebuilding T cell antigen receptor (TCR) nanoclusters and signaling across biomimetic membranes (Prof. Wolfgang Schamel, Jun. Prof. Dr. Winfried Römer)
• Controlling neuronal progenitor cell differentiation using physical cues (Prof. Prasad Shastri)
• Role of mechanobiology during epithelian and endothelian polarization and tubulogenesis (Prof. Prasad Shastri)
• The BIOSS Signal Factory: Combinatorial assembly and evolution of signaling sensors and switches (Prof. Wilfried Weber, Dr. Matthias Meier, Dr. Matias Zurbriggen)
• Study membrane protein dynamics by advanced microscopic techniques (Dr. Jiangying Yang)
• Statistical models of spatio-temporal patterns (Prof. Thomas Brox)
• Image processing for correlated light and electron microscopy (Prof. Thomas Brox)
• Refactoring nitrogen metabolism: The complex biogenesis of metal cofactors (Prof. Oliver Einsle)
• Rebuilding mitochondrial apoptosis (Prof. Georg Häcker)
• Microfluidic Proximity Analyzer (Dr. Matthias Meier)
• From single cells to artificial micro-organs on chip (Dr. Matthias Meier)
• Analysis of lipid-dependent assembly of mitochondrial outer membrane proteins using synthetic membrane systems (Prof. Chris Meisinger)